You didn't answer my first question: Does restart iRedAPD service solve this issue?
pablorvh wrote:
smtpd_end_of_data_restrictions = #check_policy_service inet:127.0.0.1:7777
smtpd_recipient_restrictions = reject_unknown_recipient_domain reject_non_fqdn_recipient reject_unlisted_recipient permit_mynetworks permit_sasl_authenticated reject_unauth_destination
You disabled iRedAPD service. But you should comment out the whole "smtpd_end_of_data_restrictions" to disable it, please fix this and restart postfix, try again.